Identifying DNA Damage caused by TOP2 enzyme

Editor's Note: This article originally appeared on Technology Networks

As a result of recent study of the DNA-cutting enzyme TOP2, scientists have created a tool that can identify specific sites of mutation across the entire genome of human leukemia cells.

The tool helps oncologists and researchers better understand the rearrangements that lead to leukemia, and will contribute to future developments in treatment.

TOP2 functions by cutting the DNA, kickstarting cellular activities like transcription and replication. The problem is, the enzyme also rejoins the cut DNA. If there is a mistake, mismatched ends can lead to the creation of abnormal white blood cells, and leukemia.

Read more from the original article on Technology Networks

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